Suplasyn® is a sterile solution of highly purified sodium hyaluronate.


Suplasyn® is a sterile solution of highly purified sodium hyaluronate. It is produced by bio-fermentation, thereby minimizing the risk of cross-species contamination or allergy to foreign proteins. Suplasyn® is sterilized by aseptic filtration.

The treatment may consist of a single injection (SUPLASYN 1-Shot, for large joints) or repeated injections, usually 3, at weekly intervals (SUPLASYN and SUPLASYN m.d.).


While symptoms may subside rapidly, the full benefits of the treatment are usually felt a few weeks after its completion.

The majority of patients experience pain relief and joint function improvement, lasting approximately 6 months, up to 12 months(1-4). This depends on the condition of the individual patient and the severity of the disease. Once the beneficial effects of a course of SUPLASYN wear off, it is possible and safe to repeat the injections.

Rest is recommended in the 48 hours following each injection and strenuous activity should be avoided during the full course of the treatment.

When is Suplasyn® indicated?

Suplasyn® has been shown to relieve pain and improve joint function in patients with mild to moderate osteoarthritis.

It can also be used as an alternative or supplement to treatment with non-steroidal anti-inflammatory drugs, the medicines most often used to treat the symptoms of osteoarthritis. Some patients do not wish to take these drugs; for other patients they are even contra-indicated.

Your doctor may decide whether Suplasyn® is right for you if you have recently been diagnosed with osteoarthritis, or if your current treatment needs to be changed or supplemented.

Possible undesirable effects of Suplasyn®

As with any intra-articular injection, there may be a mild and short-lasting discomfort during the actual procedure.

Following the injection, some patients may experience a mild local reaction like pain, feeling of heat, redness and swelling. Usually, these symptoms disappear quickly (within a few days) and without any consequence.

If these symptoms occur, rest and apply ice locally. If you feel that symptoms are severe or if they persist you should consult your physician. Do so immediately if you have fever following the injection.

Suplasyn® is CE marked in the EU as a Medical DEvice and, as such, is not considered as a drug. It contains hyaluronan, a substance that is naturally present in your joint. Suplasyn® acts locally, directly within the affected joint.